Category: Epithelial Tissue


The Body’s First Line of Defense: Exploring the specialized cellular sheets that cover, line, and protect.

Epithelial tissue, or epithelium, consists of closely packed cells with very little extracellular matrix. It forms the boundaries between our body and the external environment, lining every internal cavity and covering every external surface. From secretion in glands to absorption in the intestines, its versatility is central to human physiology.

Key Characteristics

  • Cellularity: Cells are bound closely together by specialized junctions.
  • Polarity: Features an Apical surface (top) and a Basal surface (bottom).
  • Avascularity: Contains no blood vessels; nutrients are received via diffusion from underlying connective tissue.
  • Regeneration: Highly mitotic; rapidly replaces damaged or lost cells.

Classification System

Epithelium is classified based on the number of layers and the shape of the cells at the apical surface:

By Layering:

  • Simple: A single layer (absorption/filtration).
  • Stratified: Multiple layers (protection).
  • Pseudostratified: Appears layered, but all cells touch the basement membrane.

By Cell Shape:

  • Squamous: Flat and scale-like.
  • Cuboidal: Box-like, as tall as they are wide.
  • Columnar: Tall and rectangular.

Clinical Context

Most cancers (roughly 90%) originate in epithelial tissues and are known as carcinomas. Because these cells divide rapidly and are constantly exposed to environmental carcinogens (like UV light or smoke), they are the most common site for malignant transformation.

Outline
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